Iodine/K2CO3-catalyzed synthesis of multisubstituted pyrrolidine-2-carboxylates via a one-pot reaction between an araldehyde, an amino acid ester, and a chalcone. Issue 3 (March 2019)

• Record Type: Journal Article
• Authors: Zhang, Yongjian; Su, Junyi; Lin, Tengfei; Lin, Zhangqi; Zhou, Zichun; Li, Yujin
• Is Part Of: Journal of chemical research. Volume 43:Issue 3/4(2019)
• Page Start: 90
• Page End: 96
• Publication Date: 2019-03
• Subjects: amino acid esters -- araldehydes -- chalcones -- iodine -- one-pot -- metal-free -- pyrrolidine-2-carboxylates; Chemistry -- Research -- Periodicals; Chemistry -- Periodicals; 540.5
• DOI: 10.1177/1747519819832108
• Languages: English
• ISSNs: 1747-5198

Abstract

A series of more than 20 multisubstituted pyrrolidine-2-carboxylates were synthesized via a one-pot cycloaddition of an araldehyde, an amino acid ester, and a chalcone catalyzed by I2 /K2 CO3 in tetrahydrofuran at 80 °C. The advantages of this method are readily available starting materials, mild conditions, and simple operation, and it is metal free and yields are good to excellent.