Repeatability and Reproducibility of Slit Lamp, Optical Coherence Tomography, and Scheimpflug Measurements of Corneal Scars. (4th July 2019)

• Record Type: Journal Article
• Authors: Das, Manoranjan; Menda, Shivali A.; Panigrahi, Arun K.; Venkatesh Prajna, N.; Yen, Michael; Tsang, Betty; Kumar, Alisha; Rose-Nussbaumer, Jennifer; Acharya, Nisha R.; McCulloch, Charles E.; Lietman, Thomas M.; McLeod, Stephen D.; Keenan, Jeremy D.
• Is Part Of: Ophthalmic epidemiology. Volume 26:Number 4(2019)
• Page Start: 251
• Page End: 256
• Publication Date: 2019-07-04
• Subjects: Corneal opacity -- corneal ulcer -- tomography -- optical coherence -- corneal topography -- reliability; Blindness -- Prevention -- Periodicals; Eye -- Diseases -- Epidemiology -- Periodicals; Ophthalmology -- Periodicals; 614.5997
• DOI: 10.1080/09286586.2019.1600199
• Languages: English
• ISSNs: 0928-6586

Abstract

ABSTRACT: Purpose : To determine the repeatability and reproducibility of anterior segment optical coherence tomography (AS-OCT) and Scheimpflug photography for several measurements of corneal scars, including scar size, scar depth, and corneal thickness. Methods : A series of patients treated for fungal keratitis at a tertiary eye care center in South India were recalled two years after successful treatment. Eyes with corneal scars had a slit lamp examination performed by two ophthalmologists masked to the other's examination. For AS-OCT and Scheimpflug photography, each eye had two scans taken by one technician and a third scan taken by a separate technician. Scar measurements were subsequently assessed from AS-OCT images by three graders masked to each other's results. Repeatability and reproducibility were assessed by calculating the intra-class correlation coefficient (ICC) from mixed effects linear regression models. Results : Fifty eyes had all measurements taken. The corneal scar size, measured as the geometric mean of the two longest perpendicular meridians, ranged from 0.8 to 5.4 (mean 2.8 mm, 95%CI 2.6 to 3.1). Scar size measurements taken by two separate individuals were most reproducible when the border of the scar was traced from the OCT (ICC 0.90, 95%CI 0.86 to 0.94), and least repeatable when assessed from slit lamp examination (ICC 0.80, 95%CI 0.70 to 0.90). Conclusions : AS-OCT and Scheimpflug imaging of corneal scars produced measurements with acceptable reproducibility that could be useful as cornea-specific outcomes for clinical trials.