Interethnic analyses of blood pressure loci in populations of East Asian and European descent. Issue 1 (December 2018)

• Record Type: Journal Article
• Authors: Takeuchi, Fumihiko; Akiyama, Masato; Matoba, Nana; Katsuya, Tomohiro; Nakatochi, Masahiro; Tabara, Yasuharu; Narita, Akira; Saw, Woei-Yuh; Moon, Sanghoon; Spracklen, Cassandra N.; Chai, Jin-Fang; Kim, Young-Jin; Zhang, Liang; Wang, Chaolong; Li, Huaixing; Li, Honglan; Wu, Jer-Yuarn; Dorajoo, Rajkumar; Nierenberg, Jovia; Wang, Ya; He, Jing; Bennett, Derrick; Takahashi, Atsushi; Momozawa, Yukihide; Hirata, Makoto; Matsuda, Koichi; Rakugi, Hiromi; Nakashima, Eitaro; Isono, Masato; Shirota, Matsuyuki; Hozawa, Atsushi; Ichihara, Sahoko; Matsubara, Tatsuaki; Yamamoto, Ken; Kohara, Katsuhiko; Igase, Michiya; Han, Sohee; Gordon-Larsen, Penny; Huang, Wei; Lee, Nanette; Adair, Linda; Hwang, Mi; Lee, Juyoung; Chee, Miao; Sabanayagam, Charumathi; Zhao, Wanting; Liu, Jianjun; Reilly, Dermot; Sun, Liang; Huo, Shaofeng; Edwards, Todd; Long, Jirong; Chang, Li-Ching; Chen, Chien-Hsiun; Yuan, Jian-Min; Koh, Woon-Puay; Friedlander, Yechiel; Kelly, Tanika; Wei, Wen; Xu, Liang; Cai, Hui; Xiang, Yong-Bing; Lin, Kuang; Clarke, Robert; Walters, Robin; Millwood, Iona; Li, Liming; Chambers, John; Kooner, Jaspal; Elliott, Paul; van der Harst, Pim; Chen, Zhengming; Sasaki, Makoto; Shu, Xiao-Ou; Jonas, Jost; He, Jiang; Heng, Chew-Kiat; Chen, Yuan-Tsong; Zheng, Wei; Lin, Xu; Teo, Yik-Ying; Tai, E-Shyong; Cheng, Ching-Yu; Wong, Tien; Sim, Xueling; Mohlke, Karen; Yamamoto, Masayuki; Kim, Bong-Jo; Miki, Tetsuro; Nabika, Toru; Yokota, Mitsuhiro; Kamatani, Yoichiro; Kubo, Michiaki; Kato, Norihiro;
• Is Part Of: Nature communications. Volume 9:Issue 1(2018)
• Page Start: 1
• Page End: 16
• Publication Date: 2018-12
• Subjects: Biology -- Periodicals; Physical sciences -- Periodicals; 505
• DOI: 10.1038/s41467-018-07345-0
• Languages: English
• ISSNs: 2041-1723

Abstract

Abstract Blood pressure (BP) is a major risk factor for cardiovascular disease and more than 200 genetic loci associated with BP are known. Here, we perform a multi-stage genome-wide association study for BP (maxN = 289, 038) principally in East Asians and meta-analysis in East Asians and Europeans. We report 19 new genetic loci and ancestry-specific BP variants, conforming to a common ancestry-specific variant association model. At 10 unique loci, distinct non-rare ancestry-specific variants colocalize within the same linkage disequilibrium block despite the significantly discordant effects for the proxy shared variants between the ethnic groups. The genome-wide transethnic correlation of causal-variant effect-sizes is 0.898 and 0.851 for systolic and diastolic BP, respectively. Some of the ancestry-specific association signals are also influenced by a selective sweep. Our results provide new evidence for the role of common ancestry-specific variants and natural selection in ethnic differences in complex traits such as BP. Blood pressure (BP) is a major risk factor for cardiovascular disease and more than 200 genetic loci associated with BP are known. Here, the authors perform discovery GWAS for BP in East Asians and meta-analysis in East Asians and Europeans and report ancestry-specific BP SNPs and selection signals.