The relationship between Vitamin D status and exacerbation in COPD patients– a literature review. (June 2018)

• Record Type: Journal Article
• Authors: Ferrari, Renata; Caram, Laura M.O.; Tanni, Suzana E.; Godoy, Irma; Rupp de Paiva, Sergio Alberto
• Is Part Of: Respiratory medicine. Volume 139(2018)
• Page Start: 34
• Page End: 38
• Publication Date: 2018-06
• Subjects: Chronic obstructive pulmonary disease -- Vitamin D -- Exacerbation -- Polymorphisms -- Supplementation; Chest -- Diseases -- Periodicals; Chest -- Diseases -- Great Britain -- Periodicals; Respiratory organs -- Diseases -- Periodicals; Respiratory Tract Diseases -- Periodicals; Appareil respiratoire -- Maladies -- Périodiques; Thorax -- Maladies -- Périodiques; Appareil respiratoire -- Maladies -- Traitement -- Périodiques; Electronic journals; 616.2
• DOI: 10.1016/j.rmed.2018.04.012
• Languages: English
• ISSNs: 0954-6111

Abstract

Abstract: Objective: To investigate the relationship between Vitamin D and exacerbation in COPD patients. Methods: The PubMed database was searched for articles published from 2012 onwards using search terms related to Vitamin D and exacerbation in COPD patients. Meta-analysis, clinical trials, observational studies, and human studies were included. Non-English articles or articles with full text unavailable were excluded; a total of 15 articles were selected. Results: The association between exacerbation frequency and Vitamin D levels in observational studies remains controversial, however, meta-analysis revealed a negative association between serum Vitamin D and exacerbation. Also, two clinical trials showed that Vitamin D3 supplementation in COPD patients reduced the risk of moderate and severe exacerbation. Vitamin D binding protein (VDBP) polymorphisms seem to affect patient exacerbation susceptibility. Conclusions: Few studies in literature have data related to diet, 25-hydroxyVitamin D [25(OH)D] and polymorphism in COPD exacerbation. One clinical trial indicates Vitamin D supplementation plays a role in COPD patients with hypovitaminosis D in preventing exacerbations. Further studies are needed to elucidate the role of Vitamin D in this population and to establish the best marker for Vitamin D, which patient subgroups will benefit, and the best supplement dosage without leading to toxicity.