Tumour heterogeneity and metastasis at single-cell resolution. Issue 12 (December 2018)

• Record Type: Journal Article
• Authors: Lawson, Devon; Kessenbrock, Kai; Davis, Ryan; Pervolarakis, Nicholas; Werb, Zena
• Is Part Of: Nature cell biology. Volume 20:Issue 12(2018)
• Page Start: 1349
• Page End: 1360
• Publication Date: 2018-12
• Subjects: Cytology -- Periodicals; Cells -- Periodicals; 571.605
• DOI: 10.1038/s41556-018-0236-7
• Languages: English
• ISSNs: 1465-7392

Abstract

Abstract Tumours comprise a heterogeneous collection of cells with distinct genetic and phenotypic properties that can differentially promote progression, metastasis and drug resistance. Emerging single-cell technologies provide a new opportunity to profile individual cells within tumours and investigate what roles they play in these processes. This Review discusses key technological considerations for single-cell studies in cancer, new findings using single-cell technologies and critical open questions for future applications. Lawson et al. review recent advances in single-cell technologies and discuss in detail how they can be leveraged to understand tumour heterogeneity and metastasis.