A one-pot protocol for the synthesis of β-ketosulfones from α, α-dibromoketones. Issue 15 (12th June 2019)

• Record Type: Journal Article
• Authors: Lin, Bo; Kuang, Jinqiang; Chen, Jiajia; Hua, Zhenguo; Khakyzadeh, Vahid; Xia, Yuanzhi
• Is Part Of: Organic chemistry frontiers. Volume 6:Issue 15(2019)
• Page Start: 2647
• Page End: 2653
• Publication Date: 2019-06-12
• Subjects: Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1039/c9qo00440h
• Languages: English
• ISSNs: 2052-4110

Abstract

Abstract : A one-pot debromination/sulfonylation strategy was developed for the direct transformation of α, α-dibromoketones into β-ketosulfones in the presence of sulfinate salts in a methanol solution. Abstract : A one-pot debromination/sulfonylation strategy was developed for the direct transformation of α, α-dibromoketones into β-ketosulfones in the presence of sulfinate salts in a methanol solution. A broad range of α, α-dibromoketones react smoothly with various aryl/alkyl sulfinates under neutral and catalyst-free conditions, affording diverse β-ketosulfones in good to excellent yields. The plausible mechanism was studied.