Water gated contrast switching with polymer–silica hybrid nanoparticles. Issue 59 (8th July 2019)

• Record Type: Journal Article
• Authors: Pellico, Juan; Ellis, Connor M.; Miller, Jack; Davis, Jason J.
• Is Part Of: Chemical communications. Volume 55:Issue 59(2019)
• Page Start: 8540
• Page End: 8543
• Publication Date: 2019-07-08
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c9cc03312b
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : The polymeric capping of a paramagnetically doped MSN enables the generation of high T 1 MRI contrast which is highly pH responsive through a fully reversible change in polymer conformation. Abstract : Bioresponsive contrast agents can provide smart signaling in MRI. In wrapping pore functionalised Gd-DOTA mesoporous silica nanoparticles with pH-responsive poly(acrylic acid), exchange between pore and bulk water can be reversibly switched by local pH. The generated high contrast then exhibits a large amplitude switch in a manner relevant to environmentally responsive imaging.