Heavy atom free 1, 1, 4, 4-tetraphenylbuta-1, 3-diene with aggregation induced emission for photodynamic cancer therapy. (29th May 2019)

• Record Type: Journal Article
• Authors: Wen, Huijuan; Ma, Juan; Chen, Jianjiao; Ke, Zhen; Zou, Dengfeng; Li, Qiaoyun
• Is Part Of: New journal of chemistry. Volume 43:Number 23(2019)
• Page Start: 9183
• Page End: 9187
• Publication Date: 2019-05-29
• Subjects: Chemistry -- Periodicals; Chimie -- Périodiques; 540
• DOI: 10.1039/c9nj01331h
• Languages: English
• ISSNs: 1144-0546

Abstract

Abstract : Common organic molecules usually suffer from aggregation caused quenching (ACQ), which is disadvantageous for imaging guided phototherapy. Abstract : Common organic molecules usually suffer from aggregation caused quenching (ACQ), which is disadvantageous for imaging guided phototherapy. It is of tremendous significance for a photosensitizer to be well soluble and simultaneously remain highly fluorescent in aqueous solution. Heavy atom free 1, 1, 4, 4-tetraphenylbuta-1, 3-diene (denoted asTPD ) with aggregation induced emission (AIE) was designed and synthesized by the Knoevenagel reaction. 1, 2-Distearoyl- sn-glycero -3-phospho-ethanolamine- N -[methoxy(polyethyleneglycol)-2000 ] (DSPE-PEG-2000 ) coatedTPD nanoparticles (NPs) show high singlet oxygen generation ability with singlet oxygen sensor green (SOSG) as a probe and still remain highly fluorescent in aqueous solution. In vitro cytotoxicity assay demonstrates that these NPs have a half-maximal inhibitory concentration (IC50 ) as low as 8.2 μg mL −1 . Meanwhile, in vivo fluorescence imaging shows that these NPs can passively target the tumor by the enhanced penetration and retention (EPR) effect within 6 h. Furthermore, in vivo phototherapy suggests thatTPD NPs are able to inhibit the growth of a tumor after irradiation without side effects on the normal tissues, including heart, liver, spleen, lungs and kidneys, indicating the low dark toxicity, high phototoxicity and excellent bio-compatibility of such NPs.