Fluorescence-labeled neopeltolide derivatives for subcellular localization imaging. Issue 28 (1st July 2019)

• Record Type: Journal Article
• Authors: Yanagi, Shota; Sugai, Tomoya; Noguchi, Takuma; Kawakami, Masato; Sasaki, Makoto; Niwa, Shinsuke; Sugimoto, Asako; Fuwa, Haruhiko
• Is Part Of: Organic & biomolecular chemistry. Volume 17:Issue 28(2019)
• Page Start: 6771
• Page End: 6776
• Publication Date: 2019-07-01
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c9ob01276a
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : Fluorescent-labeled neopeltolide derivatives were rationally designed for cell imaging to elucidate their localization in the mitochondria and the endoplasmic reticulum. Abstract : Design, synthesis and functional analysis of fluorescent derivatives of neopeltolide, an antiproliferative marine macrolide, are reported herein. Live cell imaging using the fluorescent derivatives showed rapid cellular uptake and localization within the endoplasmic reticulum as well as the mitochondria.