IgE-mediated histamine release from nasal mucosa is inhibited by SLPI (secretory leukocyte protease inhibitor) to the level of spontaneous release. Issue 3 (1998)

• Record Type: Journal Article
• Authors: Westin, U.; Lundberg, E.; Ohlsson, K.
• Is Part Of: Mediators of inflammation. Volume 7:Issue 3(1998)
• Page Start: 217
• Page End: 220
• Publication Date: 1998
• Subjects: SLPI -- IgE -- chymase -- histamine -- nasal mucosa; Inflammation -- Mediators -- Periodicals; Biological response modifiers -- Periodicals; Inflammation (Pathologie) -- Médiateurs; Immunomodulateurs; Biological response modifiers; Inflammation -- Mediators; Immunology; Autacoids; Immunologic Factors; Cell Adhesion Molecules; Cell Communication; Cytokines; Inflammation; Periodicals; Electronic journals; 616.0473
• DOI: 10.1080/09629359891162
• Languages: English
• ISSNs: 0962-9351

Abstract

Abstract : The secretory leukocyte protease inhibitor (SLPI) is a low-molecular-weight inhibitor of proteases, such as elastase and cathepsin G which are released from leukocytes during phagocytosis. The purpose of this study was to determine whether or not SLPI is able to inhibit IgE-mediated histamine release. Nasal mucosa from 11 test subjects without atopic disposition was used for this in vitro study. We found that SLPI inhibited histamine release in a dose-dependent way but was without influence on the spontaneous release.