Cu-Catalyzed highly selective reductive functionalization of 1, 3-diene using H2O as a stoichiometric hydrogen atom donor. Issue 59 (9th July 2019)

• Record Type: Journal Article
• Authors: Li, Qifan; Jiao, Xiaoyang; Xing, Mimi; Zhang, Penglin; Zhao, Qian; Zhang, Chun
• Is Part Of: Chemical communications. Volume 55:Issue 59(2019)
• Page Start: 8651
• Page End: 8654
• Publication Date: 2019-07-09
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c9cc04011k
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A novel high regio- and diastereo-selectivity reductive functionalization of 1, 3-diene has been developed using H2 O as a stoichiometric hydrogen atom donor. Abstract : A copper-catalyzed highly regio- and diastereo-selective reductive reaction of terminal 1, 3-diene with water and aldehyde has been developed. This chemistry afforded a product containing a terminal alkenyl group, which is a versatile kind of precursor for organic synthesis, with the scope for various substrates. The present reaction system could realize the catalytic transfer of hydrogen to diene using water as a stoichiometric H atom donor. In this transformation, B2 Pin2, a mild and practical kind of reductant was used as the mediator. The reaction pathway of this practical strategy was illustrated by a control experiment.