Cytotoxic antibiotic angucyclines and actinomycins from the Streptomyces sp. XZHG99T. (November 2018)

• Record Type: Journal Article
• Authors: Bao, Jie; He, Fei; Li, Yumei; Fang, Lei; Wang, Kaiming; Song, Jintong; Zhou, Jie; Li, Qiang; Zhang, Hua
• Is Part Of: Journal of antibiotics. Volume 71:Number 12(2018:Dec.)
• Page Start: 1018
• Page End: 1024
• Publication Date: 2018-11
• Subjects: Antibiotics -- Periodicals; 615.329
• DOI: 10.1038/s41429-018-0096-1
• Languages: English
• ISSNs: 0021-8820

Abstract

Abstract Three new angucycline-typeC -glycosides, grincamycins L–N (1 –3 ), together with the known rabelomycin (4 ), moromycin B (5 ), fridamycin D (6 ), saquayamycin B1 (7 ), actinomycin X2 (8 ), and actinomycin D (9 ), were isolated from the culture of the soil-derivedStreptomyces sp. XZHG99T collected from Color desert, Dengpa District, Tibet. The structures of1 –3 were established by detailed analyses of comprehensive spectroscopic data. Compounds1 –9 exhibited significant cytotoxicity against a panel of human cancer cell lines A549, H157, MCF7, MDA-MB-231, and HepG2, while4, 8, and9 showed decent antibacterial activity againstMycobacterium smegmatis andStaphylococcus aureus .