Design, synthesis and biological evaluation of novel 2, 3-indolinedione derivatives against mantle cell lymphoma. Issue 15 (1st August 2019)

• Record Type: Journal Article
• Authors: Yu, Shengping; Liu, Yang; Zhang, Zhen; Zhang, Jingya; Zhao, Guisen
• Is Part Of: Bioorganic & medicinal chemistry. Volume 27:Issue 15(2019)
• Page Start: 3319
• Page End: 3327
• Publication Date: 2019-08-01
• Subjects: 2, 3-Indolinedione -- Mantle cell lymphoma -- Derivatives -- Biological activities; Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; Biochemistry -- Periodicals; Chemistry, Clinical -- Periodicals; Chemistry, Organic -- Periodicals; Chimie bio-organique -- Périodiques; Chimie pharmaceutique -- Périodiques; 615.19
• DOI: 10.1016/j.bmc.2019.06.009
• Languages: English
• ISSNs: 0968-0896

Abstract

Graphical abstract: Abstract: 2, 3-Indolinedione derivatives have been identified as a novel class of promising agents for cancer treatment. In this study, eighteen 2, 3-indolinedione derivatives were designed and synthesized, and their anticancer activities against mantle cell lymphoma (MCL) cells were evaluated. Most of them exhibited significant antiproliferative activity against the tested cell lines, and compoundK5 was the most potent (MCL cellular IC50 = 0.4–0.7 μM). Further, compoundK5 could induce cell apoptosis and cell cycle arrest in G2/M phase. Additionally, the results of drug-likeness analysis demonstrated that these novel 2, 3-indolinedione derivatives could have potential as novel treatment strategies for MCL.