In vitro biological response of cancer and normal tissue cells to proton irradiation not affected by an added magnetic field. (August 2019)

• Record Type: Journal Article
• Authors: Nagle, Peter W.; van Goethem, Marc-Jan; Kempers, Marco; Kiewit, Harry; Knopf, Antje; Langendijk, Johannes A.; Brandenburg, Sytze; van Luijk, Peter; Coppes, Rob P.
• Is Part Of: Radiotherapy and oncology. Volume 137(2019)
• Page Start: 125
• Page End: 129
• Publication Date: 2019-08
• Subjects: Protons -- MRI -- Tumor -- Normal tissue -- Organoids; Oncology -- Periodicals; Radiotherapy -- Periodicals; Tumors -- Periodicals; Medical Oncology -- Periodicals; Neoplasms -- radiotherapy -- Periodicals; Radiotherapy -- Periodicals; Radiothérapie -- Périodiques; Cancérologie -- Périodiques; Tumeurs -- Périodiques; Electronic journals; 616.9940642
• DOI: 10.1016/j.radonc.2019.04.028
• Languages: English
• ISSNs: 0167-8140

Abstract

Abstract: To optimize beam delivery and conformality of proton therapy, MRI integration has been proposed. Therefore, we investigated if proton irradiation in a magnetic field would change biological responses. Our data in cancer cell lines and stem cell-derived organoid models suggest that a magnetic field does not modify the biological response.