Gliofibroma: Report of Four Cases and Review of the Literature. (2nd January 2016)

• Record Type: Journal Article
• Authors: Jones, Marta Celina; Díaz, Verónica; D'Agustini, Marcelo; Altamirano, Eugenia; Baglieri, Natalia; Drut, Ricardo
• Is Part Of: Fetal and pediatric pathology. Volume 35:Number 1(2016)
• Page Start: 50
• Page End: 61
• Publication Date: 2016-01-02
• Subjects: brain tumor -- desmoplastic astrocytoma -- gliofibroma -- spinal cord tumor; Pathology, Molecular -- Periodicals; Pediatrics -- Periodicals; Molecular biology -- Periodicals; Pediatric pathology -- Periodicals; Fetal Diseases -- pathology -- Periodicals; Infant, Newborn, Diseases -- pathology -- Periodicals; Pediatrics -- Periodicals; 618.92007
• DOI: 10.3109/15513815.2015.1122124
• Languages: English
• ISSNs: 1551-3815

Abstract

Abstract: Gliofibroma is a relatively rare variant of a mixed glial-fibrous tumor more frequent in children than in adults. It has been reported to appear all along the neuraxis, with predilection for the midline. Its evolution is usually benign, although few examples have shown either multiple sites of involvement or leptomeningeal dissemination. Some authors regard it as part of the desmoplastic astrocytoma spectrum. We report here four examples of this rare condition which exemplify its histological patterns and biological behavior, and provide a review of the literature. Even though this tumor is commonly regarded as heterogeneous and with variable course, our literature review points to a set of clinical and pathological traits that are constant, such as age, location and gross and histological characteristics, as well as a predictable evolution. Currently, this tumor is not included in the WHO Classification of CNS tumors.