Implication of dietary phthalates in breast cancer. A systematic review. (August 2018)

• Record Type: Journal Article
• Authors: Zuccarello, Pietro; Oliveri Conti, Gea; Cavallaro, Federico; Copat, Chiara; Cristaldi, Antonio; Fiore, Maria; Ferrante, Margherita
• Is Part Of: Food and chemical toxicology. Volume 118(2018)
• Page Start: 667
• Page End: 674
• Publication Date: 2018-08
• Subjects: Phthalates -- Breast cancer -- Diet -- Endocrine disruptor -- Estrogenic receptor; EDCs endocrine disrupting chemicals -- DEHP di(2-ethylhexyl) phthalate -- BBzP butylbenzyl phthalate -- DnBP di-n-butyl phthalate -- DMP dimethyl phthalate -- DEP diethyl phthalate -- MEHP mono-(2-ethylhexyl) phthalate -- MEHHP mono-(2-ethyl-5-hydroxyhexyl) phthalate -- MEOHP mono-(2-ethyl-5-oxohexyl) phthalate -- MBP mono-n-butyl phthalate -- MBzP mono-benzyl phthalate -- MEP mono-ethyl phthalate -- MMP mono-methyl phthalate -- MiBP mono-iso-butyl phthalate -- MCPP mono-(3-carboxypropyl) phthalate -- MECPP mono-(2-ethyl-5-carboxypentyl) phthalate -- PRISMA Preferred Reporting Items for Systematic Reviews and Meta-analysis -- PPAR peroxisome proliferator-activated receptor -- MDR1 multidrug resistance protein 1 -- PI3K fosfatidilinositolo-3-chinasi -- AKT protein-Kinase B -- AhR Aryl hydrocarbon receptor -- HDAC6 Histone Deacetylase 6 -- cAMP Cyclic 3′, 5′-Adenosine Monophosphate -- PKA protein-Kinase A -- MAPK mitogen-activated protein kinases -- HDAC4 Histone Deacetylase 4; Toxicology -- Periodicals; Food poisoning -- Periodicals; Food Poisoning -- Periodicals; Toxicology -- Periodicals; Toxicologie -- Périodiques; Intoxications alimentaires -- Périodiques; Food poisoning; Toxicology; Periodicals; Electronic journals; 615.9
• DOI: 10.1016/j.fct.2018.06.011
• Languages: English
• ISSNs: 0278-6915

Abstract

Abstract: Phthalates are endocrine-disrupting for their ability to change the normal function of human endocrine system. Their action on the reproductive system, both on male and female, is the most one investigated by international scientific community. The aim of this systematic review was to gather the available information regarding the role of phthalates on breast carcinogenesis focusing our research in their intake through the diet. Research was performed according the PRISMA methodology and 25 scientific articles published between 2000 and 2018 were selected. The main source of exposure to phthalates is diet, mainly through the consumption of food and beverages wrapped in different plastic packaging. Several in vitro studies suggest that certain phthalates may be associated to breast cancer since they can bind and activate the estrogen receptors. However, results of epidemiological studies are debated, yet. It's necessary to plan the future studies more carefully to have more representative data on phthalate exposure by replacing urinary matrix with piliferous one, by including as confounding factors not only the other risk factors but also prevention one as diet and miRNA expression and, finally, by direct the study considering not only the estrogenic activity of phthalates and so including also the ER negative tumors. Highlights: Several studies suggest that certain phthalates may be associated to breast cancer. It need to have replacing the urinary matrix with the piliferous one. It need to include as confounding factors also prevention one as diet and miRNA expression. It need to direct the study by including also the ER negative tumors.