Antrocarines A–F, antiplasmodial ergostane steroids from the stem bark of Antrocaryon klaineanum. (September 2015)

• Record Type: Journal Article
• Authors: Douanla, Pascal D.; Tabopda, Turibio Kuiate; Tchinda, Alembert T.; Cieckiewicz, Ewa; Frédérich, Michel; Boyom, Fabrice Fekam; Tsabang, Nole; Yeboah, Samuel; Nkengfack, Augustin E.; Tchuendem, Marguerite Hortence K.
• Is Part Of: Phytochemistry. Volume 117(2015:Sep.)
• Page Start: 521
• Page End: 526
• Publication Date: 2015-09
• Subjects: Antrocaryon klaineanum -- Anacardiaceae -- Ergostane steroids -- Antiplasmodial activities; Botanical chemistry -- Periodicals; Biochemistry -- Periodicals; Botany -- Periodicals; Chimie végétale -- Périodiques; 572.2
• DOI: 10.1016/j.phytochem.2015.07.011
• Languages: English
• ISSNs: 0031-9422

Abstract

Graphical abstract: Six new ergostane derivatives, together with two known compounds, were isolated from Antrocaryon klaineanum . The compounds were evaluated for their ability to inhibit the 3D7 strain of Plasmodium falciparum . Compounds2, 3, and8 showed potent activity. Highlights: Six new ergostane steroids (Antrocarine A–F) were isolated from A. klaineanum . Their structures were elucidated on the basis of spectroscopic methods. Extract and isolates were evaluated against 3D7 and W-2 strains of P. falciparum . Compounds1, 2, and8 exhibited potent activity with IC50 22.0, 11.2, and 21.3 μM. Abstract: During a study on the chemistry and biological activity of Antrocaryon klaineanum Pierre, six new sterols including 4, 24(28)-ergostadiene-6α, 7α-diol (1 ), 6α-methoxy-4, 24(28)-ergostadiene-7α, 20 S -diol (2 ), 6α-methoxy-4, 24(28)-ergostadien-7α-ol (3 ), 20 S -hydroxy-24(28)-ergosten-3-one (4 ), 7α-hydroxy-4, 24(28)-ergostadien-3-one (5 ), and 24(28)-ergostene-3β, 6α-diol (6 ) were characterized by physical and spectroscopic means. The known steroids7 and8 were also isolated. The crude extract and the isolated compounds were evaluated for their ability to inhibit the 3D7 strain of Plasmodium falciparum . Compounds2, 3, and8 showed potent activity while that of the crude extract was moderate.