Platycodon grandiflorum-derived saponin enhances exercise function, skeletal muscle protein synthesis, and mitochondrial function. (August 2018)

• Record Type: Journal Article
• Authors: Kim, Yong An; Jin, Sun Woo; Oh, Suck Hoon; Lee, Gi Ho; Pham, Hoa Thi; Choi, Jae Ho; Chung, Young Chul; Lee, Wang Lok; Kim, Sang Kyum; Jeong, Hye Gwang
• Is Part Of: Food and chemical toxicology. Volume 118(2018)
• Page Start: 94
• Page End: 104
• Publication Date: 2018-08
• Subjects: Platycodon grandiflorum -- Saponin -- Exercise function -- Skeletal muscle synthesis and breakdown -- Oxidative phosphorylation; CPT-1 carnitine palmitoyltranserase -- ERK extracellular-signal-regulated kinases -- mTOR mammalian target of rapamycin -- MHC myosin heavy chain -- OXPHOS Oxidative phosphorylation -- PAX7 paired-box 7 -- PS Platycodon grandiflorum derived saponin -- SDH succinate dehydrogenase -- 70S6K p70 ribosomal protein S6 kinase; Toxicology -- Periodicals; Food poisoning -- Periodicals; Food Poisoning -- Periodicals; Toxicology -- Periodicals; Toxicologie -- Périodiques; Intoxications alimentaires -- Périodiques; Food poisoning; Toxicology; Periodicals; Electronic journals; 615.9
• DOI: 10.1016/j.fct.2018.04.062
• Languages: English
• ISSNs: 0278-6915

Abstract

Abstract: Lower physical performance is an important risk factor in hypokinetic-related chronic disease, metabolic syndrome, and muscle atrophy. Our previous research demonstrated that Platycodon grandiflorum -derived saponin (PS) protects against eccentric exercise-induced muscle damage and mitochondrial function-related peroxisomal acyl-coenzme A oxidase (ACOX-1) and carnitine palmitoyltransferase (CPT-1) in high-fat diet-induced non-alcoholic steatohepatitis, and it inhibits osteoclast differentiation. However, the effects of PS on physical performance remain unknown. Therefore, we investigated whether PS enhances physical activity and skeletal muscle function. Supplementation with PS (2 mg/kg for 4 weeks) increased grip strength, wheel running repetition, and time to exhaustion in treadmill and swimming exercises. Marked increases in the synthesis of skeletal muscle proteins and muscle stem cell-related paired-box 7 (PAX7) were observed, and a decrease in the negative regulator myostatin was associated with enhanced muscle regeneration. Furthermore, PS induced expression of mitochondrial function proteins, including OXPHOS-III and -IV, in vivo and in vitro . These results suggest that PS enhances exercise function by ameliorating skeletal muscle protein synthesis and mitochondrial function. Graphical abstract: Highlights: PS enhance exercise function. PS increase protein synthesis in skeletal muscle. PS increase mitochondrial function in skeletal muscle.