A reusable magnetic nickel nanoparticle based catalyst for the aqueous synthesis of diverse heterocycles and their evaluation as potential anti-bacterial agent. Issue 18 (1st October 2018)

• Record Type: Journal Article
• Authors: Bhattacharjee, Deboshikha; Sheet, Sanjoy Kumar; Khatua, Snehadrinarayan; Biswas, Koel; Joshi, Santaram; Myrboh, Bekington
• Is Part Of: Bioorganic & medicinal chemistry. Volume 26:Issue 18(2018)
• Page Start: 5018
• Page End: 5028
• Publication Date: 2018-10-01
• Subjects: Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; Biochemistry -- Periodicals; Chemistry, Clinical -- Periodicals; Chemistry, Organic -- Periodicals; Chimie bio-organique -- Périodiques; Chimie pharmaceutique -- Périodiques; 615.19
• DOI: 10.1016/j.bmc.2018.08.033
• Languages: English
• ISSNs: 0968-0896

Abstract

Graphical abstract: Highlights: Magnetically recoverable & reusable catalyst easily prepared and utilised. Aqueous Media reaction devoid of toxic reagent. Non-chromatographic method of purification for synthesised compounds. Number of prepared derivatives found to have antimicrobial activity. Abstract: A library of biologically important heterocycles, viz. pyrazolyl pyrimidine-triones, bis(heterocyclyl)methanes were successfully synthesised by the condensation of barbituric acid, pyrazolone with an aldehyde and dimedone/4-hydoxy coumarin with various substituted aldehydes in aqueous medium at room temperature catalysed by nickel nanoparticles which proved to be an efficient magnetically recyclable catalyst. The method is simple, eco-friendly and gave excellent yields of the products without taking recourse to column chromatographic separation procedures. Computational method was employed to elucidate the selective formation of uncyclised product in reaction course. The biological activity of the synthesized compounds were investigated and the results demonstrated profound antibacterial activity.