An integrated biomarker response study explains more than the sum of the parts: Oxidative stress in the fish Australoheros facetus exposed to imidacloprid. (October 2018)

• Record Type: Journal Article
• Authors: Iturburu, Fernando G.; Bertrand, Lidwina; Mendieta, Julieta R.; Amé, María V.; Menone, Mirta L.
• Is Part Of: Ecological indicators. Volume 93(2018)
• Page Start: 351
• Page End: 357
• Publication Date: 2018-10
• Subjects: Neonicotinoid -- Integrated biomarker response index -- Antioxidant enzymes -- Oxidative damage -- Fishes; Environmental monitoring -- Periodicals; Environmental management -- Periodicals; Environmental impact analysis -- Periodicals; Environmental risk assessment -- Periodicals; Sustainable development -- Periodicals; 333.71405
• DOI: 10.1016/j.ecolind.2018.05.019
• Languages: English
• ISSNs: 1470-160X

Abstract

Graphical abstract: Highlights: Biomarkers of oxidative stress in fishes exposed to imidacloprid (IMI) were studied. An Integrated Biomarkers Response (IBR) index was used. Most important weight on IBR index were SOD activity, H2 O2 and carbonyl groups concentrations. Oxidative stress was detected in fishes exposed to 10–1000 µg/L IMI. Abstract: Integrated Biomarkers Response (IBR) index have been developed as a practical and robust tool to assess the susceptibility to pollutants using multiple biomarker responses. Neonicotinoid insecticides are nowadays one of the most sold pesticides worldwide. Nevertheless, imidacloprid (IMI) sub-lethal effects such as oxidative stress (OS) on fishes are scarcely studied. Hence, the aims of this work were: (1) to evaluate exposure- and damage biomarkers related to OS in the freshwater fish Australoheros facetus exposed to IMI and (2) to apply the IBR index to achieve a comprehensive understanding of OS in the fish. The results of the present study showed that all the biomarkers presented different responses in the three monitored tissues: liver, brain and gills. Results for an initial battery of 19 biomarkers were obtained and for the IBR index only those with significant differences have been considered. The biomarkers that had the most important weight on the IBR index were SOD activity in brain and gills, H2 O2 concentration in liver, and carbonyl groups concentration in gills in fishes exposed to 100 and 1000 μg L −1 IMI. This index allowed affirming that a short term exposure to environmentally relevant concentrations of IMI (≥10 μg L −1 ) produces OS in A. facetus . However, a more deep understanding of some biomarkers response is necessary to improve the index and for finally apply it in field studies.