Environmental styrene exposure and neurologic symptoms in U.S. Gulf coast residents. (December 2018)

• Record Type: Journal Article
• Authors: Werder, Emily J.; Engel, Lawrence S.; Richardson, David B.; Emch, Michael E.; Gerr, Fredric E.; Kwok, Richard K.; Sandler, Dale P.
• Is Part Of: Environment international. Volume 121(2018)Part 1
• Page Start: 480
• Page End: 490
• Publication Date: 2018-12
• Subjects: Air pollution -- Nervous system -- Styrene -- Biomarker -- Neurologic; Environmental protection -- Periodicals; Environmental health -- Periodicals; Environmental monitoring -- Periodicals; Environmental Monitoring -- Periodicals; Environnement -- Protection -- Périodiques; Hygiène du milieu -- Périodiques; Environnement -- Surveillance -- Périodiques; Environmental health; Environmental monitoring; Environmental protection; Periodicals; 333.705
• DOI: 10.1016/j.envint.2018.09.025
• Languages: English
• ISSNs: 0160-4120

Abstract

Abstract: Background: Styrene is an established neurotoxicant at occupational levels, but effects at levels relevant to the general population have not been studied. We examined the neurologic effects of environmental styrene exposure among U.S. Gulf coast residents. Methods: We used National Air Toxics Assessment (NATA) 2011 estimates of ambient styrene concentrations to assign exposure levels for 21, 962 non-diabetic Gulf state residents, and additionally measured blood styrene concentration in a subset of participants (n = 874). Neurologic symptoms, as well as detailed covariate information, were ascertained via telephone interview. We used log-binomial regression to estimate prevalence ratios (PR) and 95% confidence intervals (95% CI) for cross-sectional associations between both ambient and blood styrene levels and self-reported neurologic symptoms. We estimated associations independently for ten unique symptoms, as well as for the presence of any neurologic, central nervous system (CNS), or peripheral nervous system (PNS) symptoms. We also examined heterogeneity of associations with estimated ambient styrene levels by race and sex. Results: One-third of participants reported at least one neurologic symptom. The highest quartile of estimated ambient styrene was associated with one or more neurologic (PR, 1.12; 95% CI: 1.07, 1.18), CNS (PR, 1.17; 95% CI: 1.11, 1.25), and PNS (PR, 1.16; 95% CI: 1.09, 1.25) symptom. Results were less consistent for biomarker analyses, but blood styrene level was suggestively associated with nausea (PR, 1.78; 95% CI: 1.04, 3.03). In stratified analyses, we observed the strongest effects among non-White participants. Conclusions: Increasing estimated ambient styrene concentration was consistently associated with increased prevalence of neurologic symptoms. Associations between blood styrene levels and some neurologic symptoms were suggestive. Environmental styrene exposure levels may be sufficient to elicit symptomatic neurotoxic effects. Highlights: Increasing ambient styrene is consistently associated with neurologic symptoms. The strongest associations are among non-White participants. Associations between blood styrene and neurologic symptoms are only suggestive.