Greater susceptibility of girls to airborne Benzo[a]pyrene for obesity-associated childhood asthma. (December 2018)

• Record Type: Journal Article
• Authors: Choi, Hyunok; Dostal, Miroslav; Pastorkova, Anna; Rossner, Pavel; Sram, Radim J.; Ho, Shuk-Mei
• Is Part Of: Environment international. Volume 121(2018)Part 1
• Page Start: 308
• Page End: 316
• Publication Date: 2018-12
• Subjects: 8‑oxo‑dG 8‑oxo‑7, 8‑dihydro‑2′‑deoxyguanosine -- 15‑F2t‑IsoP 15‑F2t‑isoprostane -- AP attributable proportion -- B[a]P benzo[a]pyrene -- BMI body mass index -- PAH polycyclic aromatic hydrocarbon -- DEP diesel exhaust particles -- CHMI Czech Hydrometeorological Institute -- RERI relative excess risk due to interaction -- VAPS versatile air pollution sampler; Polycyclic aromatic hydrocarbon -- Benzo[a]pyrene -- Obesity -- Asthma -- Air pollution -- Sex-dimorphic; Environmental protection -- Periodicals; Environmental health -- Periodicals; Environmental monitoring -- Periodicals; Environmental Monitoring -- Periodicals; Environnement -- Protection -- Périodiques; Hygiène du milieu -- Périodiques; Environnement -- Surveillance -- Périodiques; Environmental health; Environmental monitoring; Environmental protection; Periodicals; 333.705
• DOI: 10.1016/j.envint.2018.08.061
• Languages: English
• ISSNs: 0160-4120

Abstract

Abstract: Background: Sexually dimorphic risk of obesity-associated asthma is posited to accelerate around puberty. Yet, the role of air pollution on the lean and obese asthmatic children has never been examined. Objective: To compare whether a unit exposure to airborne benzo[ a ]pyrene (B[ a ]P) is associated with altered risks of asthma across the overweight/obese (OV/OB) control, lean asthmatic, and OV/OB asthmatic children, respectively, compared to the lean controls, before and after adjusting for oxidant stress markers (i.e. 15‑F2t‑IsoP, 8‑oxo‑dG, and Carbonyl). Methods: Asthmatic and healthy control children, recruited from polluted urban and rural areas, were matched to ambient concentration of B[ a ]P. A unit increase in B[ a ]P and multinomial logistic regression on OV/OB control, lean asthmatic, and OV/OB asthma were compared across the sex- and age-groups. Results: The median B[ a ]P was associated with a linear increase among the female children, according to OV/OB and asthma, respectively, and together, compared to the lean control girls ( p = 0.001 ). While B[ a ]P was associated with positive relationship with 15‑F2t‑IsoP level among the OV/OB boys, the same exposure-outcome association was inverse among the OV/OB girls. One natural log-unit increase in ambient B[ a ]P was associated with 10.5-times greater odds (95% CI, 2.6–39.6; p = 0.001 ) the adolescent OV/OB boys, compared to the unit odds among the lean controls. In contrast, the adolescent OV/OB girls were associated with highest adjusted odds of the asthma (aOR = 15.4; 95% CI, 2.9–29.1; p < 0.001 ) compared to the lean control girls. An adjustment for 15‑F2t‑IsoP, and Carbonyls was associated with greater odds of asthma per unit exposure for the adolescent OV/OB girls (aOR = 16.2; 95% CI, 1.4–181.8; p = 0.024 ). Conclusions: B[ a ]P exposure was associated with a leap in the odds of asthma among the OV/OB adolescents, particularly the girls, after adjusting for 15‑F2t‑IsoP and Carbonyls. Highlights: Adolescent OV/OB girls experience 16-times greater asthma odds per unit B[ a ]P. Adolescent OV/OB boys experience 10.5-times greater asthma odds per unit B[ a ]P. Pre-adolescent OV/OB girls show lower oxidative stress, despite higher B[ a ]P level.