Shuffling the deck with CTLA-4 therapy: Deep sequencing of rearranged TCRB genes demonstrates T cell repertoire remodeling in cancer patients. (3rd April 2018)
- Record Type:
- Journal Article
- Title:
- Shuffling the deck with CTLA-4 therapy: Deep sequencing of rearranged TCRB genes demonstrates T cell repertoire remodeling in cancer patients. (3rd April 2018)
- Main Title:
- Shuffling the deck with CTLA-4 therapy: Deep sequencing of rearranged TCRB genes demonstrates T cell repertoire remodeling in cancer patients
- Authors:
- Cha, Edward
Fong, Lawrence - Abstract:
- ABSTRACT: CTLA-4 inhibition produces durable T cell–driven antitumor responses, but understanding which patients achieve a long-term benefit remains unclear. Deep sequencing of rearranged T cell receptor β (TCRβ) genes can monitor the effects of CTLA-4 inhibition and potentially identify patients with long-term survival.
- Is Part Of:
- Oncoimmunology. Volume 7:Number 4(2018)
- Journal:
- Oncoimmunology
- Issue:
- Volume 7:Number 4(2018)
- Issue Display:
- Volume 7, Issue 4 (2018)
- Year:
- 2018
- Volume:
- 7
- Issue:
- 4
- Issue Sort Value:
- 2018-0007-0004-0000
- Page Start:
- Page End:
- Publication Date:
- 2018-04-03
- Subjects:
- CTLA-4 -- next generation sequencing -- T cell repertoire -- ipilimumab -- tremelimumab -- immune checkpoint
Tumors -- Immunological aspects -- Periodicals
Neoplasms -- therapy -- Periodicals
Immunotherapy -- Periodicals
616.994 - Journal URLs:
- http://www.landesbioscience.com/journals/oncoimmunology/ ↗
http://www.tandfonline.com/toc/koni20/current ↗
http://www.tandf.co.uk/journals/ ↗ - DOI:
- 10.4161/21624011.2014.956016 ↗
- Languages:
- English
- ISSNs:
- 2162-402X
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - BLDSS-3PM
British Library HMNTS - ELD Digital store - Ingest File:
- 11135.xml