Thio-Michael addition of thioamides and allenes for the selective construction of polysubstituted 2-arylthiophenes via TBAI/H2O2 promoted tandem oxidative annulation and 1, 2-sulfur migration. Issue 37 (11th September 2018)

• Record Type: Journal Article
• Authors: Han, Teng; Luo, Xiaoyan
• Is Part Of: Organic & biomolecular chemistry. Volume 16:Issue 37(2018)
• Page Start: 8253
• Page End: 8257
• Publication Date: 2018-09-11
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c8ob01835a
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : TBAI/H2 O2 promoted tandem thio-Michael addition/oxidative annulation and the 1, 2-sulfur migration transformation protocol to construct polysubstituted 2-arylthiophenes. Abstract : A novel TBAI-catalyzed tandem thio-Michael addition/oxidative annulation of allenes and thioamides for the construction of polysubstituted 2-arylthiophenes under a sulfur migration transformation protocol has been developed. The transition-metal-free protocol achieves the oxidative cyclization reaction of thioamides containing electron-rich substituents with allenes to construct polysubstituted thiophenes selectively by controlling oxidation conditions.