Catalyst-free synthesis of α-thioacrylic acids via cascade thiolation and 1, 4-aryl migration of aryl alkynoates at room temperature. Issue 37 (13th September 2018)

• Record Type: Journal Article
• Authors: Wei, Wei; Wang, Leilei; Yue, Huilan; Jiang, Yuan-Ye; Yang, Daoshan
• Is Part Of: Organic & biomolecular chemistry. Volume 16:Issue 37(2018)
• Page Start: 8379
• Page End: 8383
• Publication Date: 2018-09-13
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c8ob01349g
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : A simple and facile catalyst-free strategy has been developed for the synthesis of α-thioacrylic acids from readily-available aryl alkynoates and thiols at room temperature under air. Abstract : A simple and facile catalyst-free method for the construction of α-thioacrylic acids has been developed from readily-available aryl alkynoates and thiols at room temperature. Various α-thioacrylic acids could be conveniently and efficiently obtained in moderate to good yields via cascade thiolation and 1, 4-aryl migration of aryl alkynoates in the absence of any catalyst and additive.