A novel safety assessment strategy applied to non-selective extracts. (June 2015)

• Record Type: Journal Article
• Authors: Koster, Sander; Leeman, Winfried; Verheij, Elwin; Dutman, Ellen; van Stee, Leo; Nielsen, Lene Munch; Ronsmans, Stefan; Noteborn, Hub; Krul, Lisette
• Is Part Of: Food and chemical toxicology. Volume 80(2015)
• Page Start: 163
• Page End: 181
• Publication Date: 2015-06
• Subjects: Non-selective extract -- Safety -- Complex mixture safety assessment strategy -- Threshold of toxicological concern -- TTC -- Processing; CCFM chemically complex food matrices -- CoMSAS Complex Mixture Safety Assessment Strategy -- DCHP dicyclohexylphthalate -- DCM dichloromethane -- DFB difluorobiphenyl -- DNFCS Dutch National Food Consumption Survey -- EFSA European Food Safety Authority -- EN non-selective extract of elderberry -- ER elderberry reference juice -- GC gas chromatograph -- MSTFA N-methyl-N-(trimethylsilyl)trifluoroacetamide -- NIAS non-intentionally added substances -- NSE non-selective extracts -- PN non-selective extract of pumpkin -- PR pumpkin reference juice -- SPE solid phase extraction -- SPME solid phase microextraction -- TFAA trifluoroacetylanthracene -- TTC threshold of toxicological concern -- VCF volatile compounds in foods database; Toxicology -- Periodicals; Food poisoning -- Periodicals; Food Poisoning -- Periodicals; Toxicology -- Periodicals; Toxicologie -- Périodiques; Intoxications alimentaires -- Périodiques; Food poisoning; Toxicology; Periodicals; Electronic journals; 615.9
• DOI: 10.1016/j.fct.2015.03.010
• Languages: English
• ISSNs: 0278-6915

Abstract

Highlights: Food is a complex matrix in which detection of substances in analysis and risk assessment thereof is difficult to determine. A scientific but pragmatic safety assessment strategy is used to assess a change in production of non-selective extracts. The Complex Mixture Safety Assessment Strategy is exposure driven covering newly formed and increased amounts of substances. CoMSAS enables to distinguish toxicologically relevant from less relevant substances, related to their levels of exposure. Abstract: A main challenge in food safety research is to demonstrate that processing of foodstuffs does not lead to the formation of substances for which the safety upon consumption might be questioned. This is especially so since food is a complex matrix in which the analytical detection of substances, and consequent risk assessment thereof, is difficult to determine. Here, a pragmatic novel safety assessment strategy is applied to the production of non-selective extracts (NSEs), used for different purposes in food such as for colouring purposes, which are complex food mixtures prepared from reference juices. The Complex Mixture Safety Assessment Strategy (CoMSAS) is an exposure driven approach enabling to efficiently assess the safety of the NSE by focussing on newly formed substances or substances that may increase in exposure during the processing of the NSE. CoMSAS enables to distinguish toxicologically relevant from toxicologically less relevant substances, when related to their respective levels of exposure. This will reduce the amount of work needed for identification, characterisation and safety assessment of unknown substances detected at low concentration, without the need for toxicity testing using animal studies. In this paper, the CoMSAS approach has been applied for elderberry and pumpkin NSEs used for food colouring purposes.