Functionalized prosthetic interfaces using 3D printing: Generating infection-neutralizing prosthesis in dentistry. (June 2018)

• Record Type: Journal Article
• Authors: Nagrath, Malvika; Sikora, Alexander; Graca, Jacob; Chinnici, Jennifer L.; Rahman, Saeed Ur; Reddy, Sharaschandra G.; Ponnusamy, Sasikumar; Maddi, Abhiram; Arany, Praveen R.
• Is Part Of: Materials today communications. Volume 15(2018)
• Page Start: 114
• Page End: 119
• Publication Date: 2018-06
• Subjects: 3D 3 dimensional -- PMMA poly-methyl methacrylate -- PCL poly caprolactone -- C. albicans Candida albicans -- PpX protoporphyrin-IX 3; 3D printing -- Dental materials -- Anti-fungal -- Candida -- Functionalized biointerfaces; Materials science -- Periodicals; 620.11
• DOI: 10.1016/j.mtcomm.2018.02.016
• Languages: English
• ISSNs: 2352-4928

Abstract

Graphical abstract: Generation of PMMA filaments with PCL-laden microspheres allows incorporation of biological payloads enabling 3D printing of functionalized prosthesis surfaces. Nagrath et al. (2017) Functionalized interfaces using 3d printing: generating infection-neutralizing prosthesis for clinical dentistry. Abstract: The significant incidence of fungal infections in dental prostheses that has a major impact on quality of oral and overall general health remains to be adequately addressed. Given the advances in 3D printing technologies, the current work attempted to repurpose a commonly used dental polymer, Poly methyl methacrylate (PMMA) for 3D printing along with functionalization of the tissue surface using a controlled release Polycaprolactone (PCL) microspheres containing Amphotericin-B (AmB) for anti-fungal therapy. The results demonstrate the ability of 3D printed dentures to retain comparable mechanical properties to conventional fabrication methods. Further, the PCL-PMMA surface was capable of releasing the drug over sustained time periods and was able to actively reduce Candida albicans colonization in a biomass assay. While further optimization of this platform technology is warranted, this work demonstrates the feasibility of functionalized surfaces of 3D-printed prosthesis that can provide a potent tool for various clinical therapies including splints, stents, orthopedic casts and prosthesis among others.