Association of Interleukin-8 with Cachexia from Patients with Low-Third Gastric Cancer. (26th October 2009)

• Record Type: Journal Article
• Authors: Song, Bo; Zhang, Dianliang; Wang, Shuchun; Zheng, Hongmei; Wang, Xinxiang
• Other Names: Heng H. Academic Editor.
• Is Part Of: Comparative and functional genomics. Volume 2009(2009)
• Publication Date: 2009-10-26
• Subjects: Genomics -- Periodicals; Genomes -- Periodicals; Cytogenetics -- Periodicals; 572.86
• DOI: 10.1155/2009/212345
• Languages: English
• ISSNs: 1531-6912

Abstract

Abstract : Background . Interleukin (IL)-8 has been implicated in the development of cancer cachexia. The polymorphism of IL-8 gene, which may affect the production level of IL-8, may be associated with cancer cachexia. Methods . The serum IL-8 level in our study was examined by radioimmunoassay. We also analyzed single nucleotide polymorphisms (SNPs) −251 A/T and +781 C/T of IL-8 gene, using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results . The serum levels of IL-8 were significantly elevated in patients with low-third gastric cancer compared with controls, and were further up-regulated in patients with cachexia than those without (Z = − 3.134, P = .002 ). A significantly increased frequency of +781 T allele was noted in patients with cachexia (OR = 2.247, 95% CI: 1.351–3.737, P = .002 ). The +781 TT genotype was observed to be associated with a significantly increased risk of cachexia (OR = 3.167, 95% CI: 1.265–7.929, P = .011 ), and with odds ratio of 3.033 (95% CI: 1.065–8.639, P = .038 ) for cachexia after adjusting for potential confounding factors. Meanwhile, haplotype analysis indicated a borderline positive association betweenT 251 T 781 haplotype and cachexia as compared with theT 251 C 781 haplotype (OR = 4.92, 95% CI: 1.00–24.28;, P = .053 ). Conclusions . IL-8 appears to be associated with cachexia from patients with low-third gastric cancer.