Non-invasive blood glucose measurement by near infrared spectroscopy: Machine drift, time drift and physiological effect. Issue 6 (2010)

• Record Type: Journal Article
• Authors: Lam Lam, Simon C. H. Simon C. H.; Chung Chung, Joanne W. Y. Joanne W. Y.; Fan Fan, K. L. K. L.; Wong Wong, Thomas K. S. Thomas K. S.
• Is Part Of: Spectroscopy. Volume 24:Issue 6(2010)
• Page Start: 629
• Page End: 639
• Publication Date: 2010
• Subjects: Spectroscopy -- machine drift -- time drift -- physiological effect -- PLS -- PDS -- Beer's law
• DOI: 10.3233/SPE-2010-0485
• Languages: English
• ISSNs: 0712-4813

Abstract

Abstract : The aim of this paper is to evaluate development of the non-invasive blood glucose measurement of near infrared (NIR) spectroscopy. The results showed that NIR spectroscopy might obtain glucose concentration of up to 200% difference under a same environmental condition with two months apart due to time and machine drifts. These effects can restrict the development of the non-invasive blood glucose measurement. Partial least square (PLS) regression was used, which showed advantage over using simple absorbance for glucose concentration. Non-invasive blood glucose measurement of health subjects (non-diabetics) was also investigated. The results showed that R correlation coefficient of prediction ( R p ) was 0.48 and root mean square of prediction (rmsep) was 1.34 mmol/l. The error was mainly due to the physiological effect of different subjects.