Differences between infrared spectra of normal and neoplastic human gastric cells. Issue 1 (2004)

• Record Type: Journal Article
• Authors: Fujioka Fujioka, Naoko Naoko; Morimoto Morimoto, Yuji Yuji; Arai Arai, Tsunenori Tsunenori; Takeuchi Takeuchi, Kyoko Kyoko; Yoshioka Yoshioka, Masahiko Masahiko; Kikuchi Kikuchi, Makoto Makoto
• Is Part Of: Spectroscopy. Volume 18:Issue 1(2004)
• Page Start: 59
• Page End: 66
• Publication Date: 2004
• DOI: 10.1155/2004/347480
• Languages: English
• ISSNs: 0712-4813

Abstract

Abstract : We investigated the differences in Fourier transform‒infrared (FT‒IR) spectra between normal and neoplastic human gastric cells. The infrared spectra derived from the cancer cells (AGS, SNU‒1, and NCI‒N87) showed a significant increase in infrared absorption in the band around 1240 cm¯ 1, 1120 cm¯ 1 and 1080 cm¯ 1, compared with those from the normal gastric epithelial cells we established in culture. In addition, frequency shifts of 4.6 cm¯ 1 and 3.8 cm¯ 1 were seen at the peak absorbance in the bands around 1240 cm¯ 1 and 1080 cm¯ 1, respectively. These spectral differences reflected the differences between the phosphate backbone in the normal and neoplastic human gastric cells. The present results suggest that FT‒IR spectroscopy is a potential new tool for gastric cancer diagnosis.