Changes in cerebral hemodynamics during a sleep-deprived video-electroencephalogram in healthy children. (31st May 2016)

• Record Type: Journal Article
• Authors: Peng, Bingwei; Li, Jialing; Wang, Jing; Liang, Xiuqiong; Zheng, Zhiying; Mai, Jianning
• Is Part Of: Physiological measurement. Volume 37:Number 7(2016:Jul.)
• Page Start: 981
• Page End: 989
• Publication Date: 2016-05-31
• Subjects: cerebral hemodynamics -- sleep-deprived video-electroencephalogram (SD-VEEG) -- children -- transcranial Doppler ultrasound -- neurovascular coupling; Physiology -- Measurement -- Periodicals; Patient monitoring -- Periodicals; 612
• DOI: 10.1088/0967-3334/37/7/981
• Languages: English
• ISSNs: 0967-3334

Abstract

Abstract: This study investigates the cerebral hemodynamic changes during a routine sleep-deprived video-electroencephalogram (SD-VEEG) in healthy children. Forty-two children with normal intelligence were examined. The children were 5–14 years of age, and their electroencephalograms (EEGs) were within the normal range. Each subject was deprived of a routine night's sleep and then examined during non-drug-induced sleep in the daytime. The awake and sleep stages were evaluated using EEGs, according to the American Academy of Sleep Medicine. Stable transcranial Doppler ultrasound (TCD) tracings through real-time TCD-VEEG monitoring were recorded. The mean systolic cerebral blood flow velocity (CBFV), diastolic CBFV, pulsatility index and resistance index of each artery were analyzed for 30 s per stage. A multivariate analysis of variance was conducted to compare the hemodynamic parameters for the awake stage versus light sleep and deep sleep stages. Non-rapid eye movement sleep was associated with an increased CBFV in the middle (164.38 ± 27.28) and anterior cerebral artery (131.81 ± 21.55) during light sleep (stages N1 and N2) ( P = 0.0001), a reduced systolic CBFV in all vascular arteries (LMCA, 138.73 ± 20.64; LACA, 108.33 ± 22.33; LPCA, 83.9 ± 18.6) during deep sleep (stage N3) compared with light sleep ( P = 0.0001), and a sustained increased PI (LMCA, 0.92 ± 0.13; LACA, 0.964 ± 0.18) during deep sleep ( P < 0.05). These findings indicate distinct cerebral hemodynamic alterations during SD-VEEG in children. This study utilized real-time TCD-VEEG monitoring during SD-EEG to further investigate neurovascular coupling in interictal epileptic discharges and understand its potential influence on cognition in the developing brain.