Novel murine tumour models depend on strain and route of inoculation1. Issue 4 (28th July 2016)

• Record Type: Journal Article
• Authors: Fu, Qiang; Satterlee, Andrew; Wang, Yongjun; Wang, Yuhua; Wang, Dun; Tang, Jingling; He, Zhonggui; Liu, Feng
• Is Part Of: International journal of experimental pathology. Volume 97:Issue 4(2016:Aug.)
• Page Start: 351
• Page End: 356
• Publication Date: 2016-07-28
• Subjects: B16F10 -- hydrodynamic injection -- intravenous -- lung metastasis -- tumour growth -- tumour location; Pathology, Experimental -- Periodicals; 616.07
• DOI: 10.1111/iep.12192
• Languages: English
• ISSNs: 0959-9673

Abstract

Summary: This study describes variations in tumour growth patterns which occur when changes in the routes of inoculation and mouse strain are used to introduce tumours into established murine model systems that are known to vary in location and aggression. Intraperitoneal, subcutaneous, intravenous and hydrodynamic inoculations of B16F10 cells were compared among CD‐1, C57BL/6 and Balb/c mice. Most surprisingly, allogeneic tumour growth in Balb/c mice after intravenous and hydrodynamic inoculation of B16F10 cells was faster than tumour growth in the syngeneic C57BL/6 mice. These and other variations in the tumour growth patterns described here can help provide the researcher with more experimental control when planning to use the optimal tumour model for any particular study.