Role of physical activity in cartilage damage progression of subjects with baseline full-thickness cartilage defects in medial tibiofemoral compartment: data from the Osteoarthritis Initiative. Issue 11 (November 2016)

• Record Type: Journal Article
• Authors: Kwee, R.M.; Wirth, W.; Hafezi-Nejad, N.; Zikria, B.A.; Guermazi, A.; Demehri, S.
• Is Part Of: Osteoarthritis and cartilage. Volume 24:Issue 11(2016)
• Page Start: 1898
• Page End: 1904
• Publication Date: 2016-11
• Subjects: Knee -- Osteoarthritis -- Denuded bone -- Cartilage -- Progression -- Physical activity; Osteoarthritis -- Periodicals; Cartilage -- Periodicals; Osteoarthritis -- Periodicals; Cartilage -- Periodicals; Arthrose -- Périodiques; Articulations -- Maladies -- Périodiques; 616.7223005
• DOI: 10.1016/j.joca.2016.06.009
• Languages: English
• ISSNs: 1063-4584

Abstract

Summary: Objective: To assess the association between physical activity and cartilage damage progression in medial tibiofemoral compartment (MTFC) using 2-year follow-up magnetic resonance imaging (MRI) in subjects with denuded areas of subchondral bone (dABs) at the central weight-bearing medial femur (cMF) at baseline MRI examination. Methods: One hundred subjects from the Osteoarthritis Initiative (OAI) progression cohort with dABs at the cMF at 3T MRI at baseline (51% men; mean age 62.2 years, range 45–79) were included. Sagittal 3D dual-echo steady-state with water excitation images were used to assess 2-year MTFC cartilage change. Associations between 2-year average Physical Activity Scale for the Elderly (PASE) and 2-year MTFC cartilage change were assessed by linear regression analysis. Subgroup analyses were performed. Results: No associations between PASE and 2-year MTFC cartilage change were observed in the entire cohort. Similarly, in the subgroup with cartilage loss during the 2 years, the non-refuted confidence intervals for the regression coefficients were tightly clustered around the null value (regression coefficients for: mean cMF.ThCtAB = −0.00059; 98.75% CI: −0.00130 to 0.00012), cMF.dAB% = 0.02176; 98.75% CI: −0.02514 to 0.06865, Mean MT.ThCtAB = −0.00013; 98.75% CI: −0.00064 to 0.00038, MT.dAB% = 0.02543; 98.75% CI: −0.01485 to 0.06571. Conclusion: In the entire group of subjects with dABs at the cMF at baseline, no association between physical activity and 2-year MTFC cartilage change was detected. Due to the limited sample size of our study, small-sized effects may not have been detected in our study.