PS 14-86 LEFT VENTRICLE SYSTOLIC LONGITUDINAL DYSFUNCTION AND LV DIASTOLIC DYSFUNCTION IN HYPERTENSIVE PATIENTS: CLOSING THE GAP. (September 2016)

• Record Type: Journal Article
• Authors: Castanheira, Joaquim; Duarte, Mónica; Pereira, Telmo; Conde, Jorge
• Is Part Of: Journal of hypertension. Volume 34:(2016) Supplement 1
• Publication Date: 2016-09
• Subjects: Hypertension -- Periodicals; Hypertension -- Periodicals; 616.132005
• DOI: 10.1097/01.hjh.0000501207.70308.29
• Languages: English
• ISSNs: 1473-5598

Abstract

Abstract : Objective: Hypertension (HT) is a multifactorial disease with high incidence and prevalence, strongly associated with cardiovascular mortality and morbidity. The left ventricle (LV) is a major target organ of HT. Our aim was to evaluate cardiac structural changes arising from HT, with particular emphasis on the relationship between the longitudinal systolic and diastolic dysfunction of the LV. Design and Method: We conducted a cross-sectional study, enrolling 60 hypertensive (HG) patients and a group of 60normotensive and healthy subjects, matched for age and gender (control group- CG). Inclusion criteria for the HG was taking at least one antihypertensive drug and the absence of comorbidities. All patients underwent transthoracic echocardiography, complemented with Tissue Doppler analysis (TDI), by the same operator. Results: The A wave and the septal and lateral E/E' ratios, were significantly higher (p < 0.0001), and the E/A ratio significantly lower (p < 0.0001), in the HG compared to the CG. The Vp had a significantly lower mean value in hypertensive patients (p < 0.0001). The mean S-wave velocity was significantly lower, and the mean A'-wave velocity significantly higher, in the HG compared to the CG (p < 0.0001 for both comparisons). A positive linear relationship between Sm and E'm was also depicted (p < 0.001). Also, LV mass index and ejection fraction was significantly correlated with LV longitudinal function estimates. Conclusions: The results indicate that the contraction and relaxation of the longitudinal fibers of the LV are interdependent processes, revealing subtle functional changes in hypertensive patients with preserved ejection fraction and with slight or no increase in ventricular mass.