PS 09-09 ELEVATED PLASMA TGF-1 LEVELS PREDICTED THE DEVELOPMENT OF HYPERTENSION IN NORMOTENSIVES IN A GENERAL POPULATION. (September 2016)

• Record Type: Journal Article
• Authors: Nakao, Erika; Adachi, Hisashi; Enomoto, Mika; Fukami, Ako; Kumagai, Eita; Nakamura, Sachiko; Nohara, Yume; Morikawa, Nagisa; Kono, Shyoko; Sakaue, Akiko; Tsuru, Tomoko
• Is Part Of: Journal of hypertension. Volume 34:(2016) Supplement 1
• Publication Date: 2016-09
• Subjects: Hypertension -- Periodicals; Hypertension -- Periodicals; 616.132005
• DOI: 10.1097/01.hjh.0000500789.39699.99
• Languages: English
• ISSNs: 1473-5598

Abstract

Abstract : Objective: Transforming growth factor β1 (TGF-β1) is a multifunctional cytokine. There is evidence that TGF-β1 is involved in the pathogenesis of hypertension and the development of hypertensive target organ damage. However, most large scale cross-sectional studies in humans have indicated no relationship between plasma TGF-β1 levels and hypertension. The present study was designed to determine whether elevated TGF-β1 levels predict the development of hypertension. Design and Method: In 2002–2004, in a fishing community in southwestern Japan (Uku town), a total of 528 people received a health examination. We examined blood pressure, body mass index (BMI) and blood chemistries. Data on fasting plasma TGF-β1 were obtained from 528 individuals. Of these, 149 normotensives (blood pressure <140/90 mmHg without anti-hypertensive medications) at baseline were followed-up during over ten years. Results: Of 149 normotensives at baseline, 59 subjects developed hypertension. We divided the baseline plasma TGF-β1 levels into tertiles. The odds ratio [1.126 (95% CI, 0.461–2.752)] for the development of hypertension after 10 years was not statistically significant in the highest tertiles vs. the lowest tertiles of plasma TGF-β1 level after adjustment for confounding factors. However, a significant trend (p = 0.018 for trend) was found among the three groups. Conclusions: Elevated plasma TGF-β1 levels predicted the development of hypertension in normotensives in community-dwelling Japanese.