Pigmented Villonodular Synovitis: A Comprehensive Review and Proposed Treatment Algorithm. Issue 7 (19th July 2016)

• Record Type: Journal Article
• Authors: Stephan, Stephen R.; Shallop, Brandon; Lackman, Richard; Kim, Tae Won B.; Mulcahey, Mary K.
• Is Part Of: JBJS reviews. Volume 4:Issue 7(2016)
• Publication Date: 2016-07-19
• Subjects: Bones -- Surgery -- Periodicals; Joints -- Surgery -- Periodicals; Orthopedics -- Periodicals; Orthopedics; General Surgery; Bone Diseases; Joint Diseases; Bones -- Surgery; Joints -- Surgery; Orthopedics; Periodicals; Electronic journals; Periodicals; 617.47
• DOI: 10.2106/JBJS.RVW.15.00086
• Languages: English
• ISSNs: 2329-9185

Abstract

Abstract : Evidence now exists suggesting a neoplastic origin for pigmented villonodular synovitis, including a thorough description of the translocations involved. Arthroscopic excision for localized pigmented villonodular synovitis allows for both minimal recurrence and morbidity when compared with open excision; however, open excision still plays an important role in treating posterior compartment nodules. The optimal surgical treatment for diffuse pigmented villonodular synovitis is still a matter for debate, with combined anterior arthroscopic and open posterior excision being considered the preferred method. Radiation therapy has re-emerged as an additional treatment method for pigmented villonodular synovitis; however, the potential for serious toxicity makes it a questionable option, especially for such a benign condition. Small molecule and monoclonal antibody targeted therapies are being investigated as novel treatment methods for pigmented villonodular synovitis, with promising results.