Insulin clearance: an underappreciated modulator of plasma insulin concentration. Issue 7 (October 2016)

• Record Type: Journal Article
• Authors: Kim, Sun H; Reaven, Gerald M
• Is Part Of: Journal of investigative medicine. Volume 64:Issue 7(2016)
• Publication Date: 2016-10
• Subjects: Insulin -- Diabetes Mellitus -- Glucose; Clinical medicine -- Periodicals; Medicine -- Research -- Periodicals; Medicine; Research -- United States; Clinical medicine; Medicine -- Research; Periodicals; 616.075
• DOI: 10.1136/jim-2016-000149
• Languages: English
• ISSNs: 1081-5589

Abstract

Abstract : Plasma glucose concentrations are tightly regulated and maintained within a narrow range in non-diabetic individuals. Maintenance of this physiological state is primarily a function of the ability of the pancreatic β-cells to modify insulin secretion rate (ISR), thus preventing wide-swings in plasma glucose concentrations. As a consequence, and in contrast to plasma glucose concentrations, plasma insulin concentrations vary substantially in non-diabetic individuals. Although differences in ISR are primarily responsible for the variability in plasma insulin concentration, there is increasing evidence that differences in insulin clearance rate (ICR) also play a role in regulation of plasma insulin concentration. The goal of this mini-review is to highlight situations that demonstrate the important role of ICR in both insulin and glucose homeostasis.