Increased cardiorespiratory coordination in preeclampsia. (27th April 2017)

• Record Type: Journal Article
• Authors: Berg, Karsten; Kraemer, Jan F; Riedl, Maik; Stepan, Holger; Kurths, Jürgen; Wessel, Niels
• Is Part Of: Physiological measurement. Volume 38:Number 5(2017:May)
• Page Start: 912
• Page End: 924
• Publication Date: 2017-04-27
• Subjects: EDR -- respiration -- cardirespiratory coupling -- preeclampsia -- cardiorespiratory coordigram -- biosignal analysis; Physiology -- Measurement -- Periodicals; Patient monitoring -- Periodicals; 612
• DOI: 10.1088/1361-6579/aa64b0
• Languages: English
• ISSNs: 0967-3334

Abstract

Abstract: Preeclampsia is one of the main sources of morbidity in pregnancy with a high mortality rate without a known ultimate cause. Using a corpus including 927 measurements of pregnant women with and without different hypertonic diseases at multiple stages of pregnancy, we utilised a new approach to analyse cardiorespiratory coordination. Since the recording quality of respiratory effort was limited due to a high signal to noise ratio, we applied an ECG derived respiration approach to create an ersatz respiratory signal. After applying the few available recordings with a sufficiently high quality of the respiratory signal to validate the substitute, coordigrams were calculated and quantified by utilising an epsilon method. We showed significant ( p < 0.05) differences in the coordination in a matched (BMI, age, gestational week) comparison of preeclamptic and healthy subjects. Hopefully future applications of and improvements on these methods are able to create a fast and convenient prediction methodology to reduce the impact of this disease as well as help in the determination of its underlying cause.