Anti-tumor immune response induced by nanosecond pulsed streamer discharge in mice. (17th February 2017)

• Record Type: Journal Article
• Authors: Mizuno, Kazue; Yonetamari, Kenta; Shirakawa, Yuki; Akiyama, Taketoshi; Ono, Ryo
• Is Part Of: Journal of physics. Volume 50:Number 12(2017)
• Publication Date: 2017-02-17
• Subjects: plasma medicine -- mouse melanoma tumor -- innate immune response -- adaptive immune response -- in vivo -- pulsed streamer discharge -- cancer treatment; Physics -- Periodicals; 530
• DOI: 10.1088/1361-6463/aa5dbb
• Languages: English
• ISSNs: 0022-3727

Abstract

Abstract: Plasma is known to activate immune cells in vitro ; however, its effect on cancer immunotherapy is not well understood in vivo . In this study, we report B16–F10 tumor growth suppression at a non-irradiated site on a mouse leg after a nanosecond pulsed streamer discharge was applied to the tumor on the other leg. The tumor growth suppression at non-irradiated remote sites was observed from the day next to that of plasma irradiation: the rapid abscopal effect suggests innate immune response activation. Additionally, the production of inflammatory cytokines from splenocytes was enhanced after plasma irradiation. This suggests the activation of adaptive immune response specific to B16–F10 melanoma by plasma irradiation.