Hybrid mesoporous silica nanospheres modified by poly (NIPAM-co-AA) for drug delivery. (11th June 2019)

• Record Type: Journal Article
• Authors: Zhang, Keju; Zhou, Dong; Wang, Zhiguo; Zhang, Yuhong; He, Peixin
• Is Part Of: Nanotechnology. Volume 30:Number 35(2019)
• Publication Date: 2019-06-11
• Subjects: mesoporous silica -- ethane-bridged nanoparticles -- thermal/pH sensitivity -- drug delivery -- two silicon source; Nanotechnology -- Periodicals; Nanotechnology -- Periodicals; Nanotechnology; Publications périodiques; Nanotechnologies; Periodicals; 620.5
• DOI: 10.1088/1361-6528/ab209d
• Languages: English
• ISSNs: 0957-4484

Abstract

Abstract: The synthesis of drug delivery systems based on surface-modified mesoporous silica hollow structures remains a huge challenge. In this paper, we have obtained hollow mesoporous silica nanoparticles (MSNs) by surfactant directed sol-gel assisted hydrothermal treatment. The MSNs have the inorganic-organic hybrid frameworks with uniform diameter distribution (260 nm), and their specific surface area, mesoporous size and pore volume are 540 m 2 g −1, 3.7 nm, 0.58 cm 3 g −1, respectively. It was proved that the preparation of hollow ethane-bridged nanospheres with two silicon source was due to the high crosslinking of the silicone interface and hydrothermal treatment, providing a new approach for the study of drug-loaded and controlled release behavior. Based on the synthesis of MSNs, MSNs were modified by methacryloxy propyl trimethoxyl silane (MPS) on the surface of MSNs. Then N-isopropylacryamide (NIPAM) and acrylic acid (AA) were grafted onto the surface of modified MSNs. The hollow ethane-bridged PNA–MSNs (poly (NIPAM-co-acrylic acid)-MSNs) with two silicon source were prepared successfully. Due to their distinctive hollow structure, PNA–MSNs demonstrated high drug encapsulation efficiency (70.4% ± 2.9%). The experiment results proved that the modified hollow nanoparticles not only had good biocompatibility and stability, but also possessed pH-/thermal-dual responsiveness in drug release.