Full-range ultrahigh-resolution spectral-domain optical coherence tomography in 1.7 µm wavelength region for deep-penetration and high-resolution imaging of turbid tissues. (14th November 2016)

• Record Type: Journal Article
• Authors: Kawagoe, Hiroyuki; Yamanaka, Masahito; Makita, Shuichi; Yasuno, Yoshiaki; Nishizawa, Norihiko
• Is Part Of: Applied physics express. Volume 9:Number 12(2016:Dec.)
• Publication Date: 2016-11-14
• Subjects: Physics -- Periodicals; Technology -- Periodicals; 621.05
• DOI: 10.7567/APEX.9.127002
• Languages: English
• ISSNs: 1882-0778

Abstract

Abstract: For the first time, we developed a full-range ultrahigh-resolution (UHR) spectral-domain optical coherence tomography (SD-OCT) technique working in the 1.7 µm wavelength region. This technique allowed high-resolution, deep-tissue imaging. By using a supercontinuum source operating at a wavelength of 1.7 µm, an axial resolution of 3.6 µm in a tissue specimen was achieved. To enhance the imaging depth of UHR-SD-OCT, we performed full-range OCT imaging based on a phase modulation method. We demonstrated the three-dimensional (3D) imaging of a mouse brain with the developed system, and specific structures in the mouse brain were clearly visualized at depths up to 1.7 mm.