Perianal Goblet Cell Carcinoid With Pagetoid Spread. (October 2019)

• Record Type: Journal Article
• Authors: Grunes, Dianne; Kim, Michelle Kang; Chessin, David B.; Yaeger, Rona D.; Ward, Stephen C.
• Is Part Of: International journal of surgical pathology. Volume 27:Number 7(2019)
• Page Start: 788
• Page End: 791
• Publication Date: 2019-10
• Subjects: goblet cell carcinoid -- pagetoid spread -- perianal; Pathology, Surgical -- Periodicals; 617.07
• DOI: 10.1177/1066896919845478
• Languages: English
• ISSNs: 1066-8969

Abstract

We present a case of perianal goblet cell carcinoid with pagetoid spread. Goblet cell carcinoid, also known as adenocarcinoid tumor, predominantly arises as a primary appendiceal tumor and contains nests of neuroendocrine and mucin-containing cells. When this tumor type is seen in other sites it usually represents a metastasis. We present the case of an 81-year-old woman with a perianal mass. Histologic and immunohistochemical examination following surgical excision showed a goblet cell carcinoid demonstrating pagetoid spread along the perianal squamous mucosa. There was no evidence of a primary appendiceal tumor by history or imaging studies. To our knowledge, this is the first report of a goblet cell carcinoid presenting in this manner. The patient died due to complications of metastatic disease 26 months after initial diagnosis.