TiO2 nanocomposite for the controlled release of drugs against pathogens causing wound infections. (6th February 2018)

• Record Type: Journal Article
• Authors: Venkatasubbu, G Devanand; Nagamuthu, S; Anusuya, T; Kumar, J; Chelliah, Ramachandran; Ramakrishnan, Sudha Rani; Antony, Usha; Khan, Imran; Oh, Deog-Hwan
• Is Part Of: Materials research express. Volume 5:Number 2(2018)
• Publication Date: 2018-02-06
• Subjects: titanium dioxide -- chitosan -- ciprofloxacin -- amoxicillin -- curcumin -- wound healing; Materials science -- Research -- Periodicals; Materials science -- Periodicals; 620.11
• DOI: 10.1088/2053-1591/aaa936
• Languages: English
• ISSNs: 2053-1591

Abstract

Abstract: Chitosan titanium dioxide nanocomposite has been used for wound healing. Titanium dioxide (TiO2 ) nanoparticles are synthesised and made in to nanocomposite along with chitosan. Curcumin nanoparticles are synthesised. Three different drugs with antimicrobial activity are incorporated into the chitosan/TiO2 nanocomposite. Ciprofloxacin, amoxicillin and curcumin nanoparticles are incorporated within the chitosan/TiO2 nanoparticles. The nanoparticles and nanocomposite are characterized with XRD, FTIR, TEM and SEM. Drug loading was found to be around 45% for all the three drug molecules. The drug release profile shows a controlled release of drug molecules from the nanocomposite. Antibacterial studies shows a good inhibition of bacterial species by the nanocomposites.