Biomimetic synthesis of novel polyvinyl alcohol/hydroxyapatite composite microspheres for biomedical applications. (7th September 2018)

• Record Type: Journal Article
• Authors: Xue, Ke; Teng, Shu-Hua; Niu, Niu; Wang, Peng
• Is Part Of: Materials research express. Volume 5:Number 11(2018)
• Publication Date: 2018-09-07
• Subjects: polyvinyl alcohol -- biomimetic -- composite microspheres -- in-situ synthesis -- drug delivery; Materials science -- Research -- Periodicals; Materials science -- Periodicals; 620.11
• DOI: 10.1088/2053-1591/aadc7d
• Languages: English
• ISSNs: 2053-1591

Abstract

Abstract: Biomimetic composite microspheres of polyvinyl alcohol/hydroxyapatite (PVA/HA) were fabricated for the first time via a synergy of in situ synthesis and emulsification-crosslinking process for biomedical applications. The influences of the HA contents on their phases and morphological features were investigated. The results showed that, when 20 wt% HA was incorporated, the as-prepared PVA/HA composite microspheres exhibited a regular spherical shape, high dispersity and uniform microstructure. Their average particle size was determined as about 39.0 μ m. The in situ deposited inorganic phase of the composite microspheres was identified as low-crystalline HA, and its actual content was in close agreement with the theoretical value. After being soaked in simulated body fluid (SBF), the PVA-20%HA composite microspheres were covered with bone-like apatite particles, indicating their good in vitro bioactivity. Vancomycin hydrochloride (VH) was chosen as a model drug. The drug entrapment efficiency and drug loading capacity of the microspheres were found to gradually increase with the increase of HA content. Moreover, the PVA/HA composite microspheres were more effective for releasing VH in a controlled way than their PVA equivalents, among which those containing 20 wt% HA exhibited the best drug release behavior.