Surface colonized silver nano particles over chitosan poly-electrolyte micro-spheres and their multi-functional behavior. (23rd February 2018)

• Record Type: Journal Article
• Authors: Prakash, B; Asha, S; Ananth, A Nimrodh; Vanithakumari, G; Okram, G S; Jose, Sujin P; Rajan, M A Jothi
• Is Part Of: Materials research express. Volume 5:Number 2(2018)
• Publication Date: 2018-02-23
• Subjects: theranostics -- silver nanoparticles -- cytotoxicity -- chitosan -- reactive oxygen species -- antibacterial properties; Materials science -- Research -- Periodicals; Materials science -- Periodicals; 620.11
• DOI: 10.1088/2053-1591/aaa3c6
• Languages: English
• ISSNs: 2053-1591

Abstract

Abstract: Chitosan/tripolyphosphate polyelectrolyte (TPP) microspheres, decorated and surface functionalized with silver nanoparticles (NPs) of average diameter of 15 nm, were synthesized following a simple two-step procedure. These Ag NP-functionalized polyelectrolyte microspheres (Ag-CSPMs) are found to be biocompatible and enhancing the reactive oxygen species in curcumin with excellent anti-bacterial activity for selected Gram-positive and negative bacterial strains, making them much attractive relative to bare surface counterparts; the well-stabilized silver NPs do not form any agglomerations on the surface of the chitosan microspheres. They also show excellent cytotoxic behavior towards MCF7 cell lines, showing a half-maximal inhibitory concentration (IC50 ) of 32 μ g ml −1 . Therefore, Ag-CSPMs exhibit multi-functional ability having potential towards theranostics applications.