3D bioprinting of triphasic nanocomposite hydrogels and scaffolds for cell adhesion and migration. (31st May 2019)

• Record Type: Journal Article
• Authors: Motealleh, Andisheh; Dorri, Pooya; Schäfer, Andreas H; Kehr, Nermin S
• Is Part Of: Biofabrication. Volume 11:Number 3(2019)
• Publication Date: 2019-05-31
• Subjects: 3D bioprinting -- nanocomposite hydrogels -- scaffolds -- cell adhesion -- cell migration; Biomedical engineering -- Periodicals; Tissue engineering -- Periodicals; Biomedical materials -- Microstructure -- Periodicals; Bioengineering -- Periodicals; 610.28
• DOI: 10.1088/1758-5090/ab15ca
• Languages: English
• ISSNs: 1758-5082

Abstract

Abstract: In this study we describe the first example of 3D bioprinted triphasic chiral nanocomposite (NC) hydrogels/scaffolds to simulate the complex 3D architecture, nano/micro scale topography, and chiral nature of extracellular matrix. These multifunctional constructs are prepared using a 3D bioprinting technique and are composed of three connected hydrogels/scaffolds, two of which are loaded with nanomaterials functionalized with opposite enantiomers of a biomolecule. With these constructs, we direct the migration of cells toward the part of the triphasic chiral NC hydrogels/scaffolds containing the cells' preferred biomolecule enantiomer.