Metastable crystal growth of acetaminophen using solution-mediated phase transformation. (13th December 2016)

• Record Type: Journal Article
• Authors: Mori, Yoichiro; Maruyama, Mihoko; Takahashi, Yoshinori; Yoshikawa, Hiroshi Y.; Okada, Shino; Adachi, Hiroaki; Sugiyama, Shigeru; Takano, Kazufumi; Murakami, Satoshi; Matsumura, Hiroyoshi; Inoue, Tsuyoshi; Yoshimura, Masashi; Mori, Yusuke
• Is Part Of: Applied physics express. Volume 10:Number 1(2017)
• Publication Date: 2016-12-13
• Subjects: Physics -- Periodicals; Technology -- Periodicals; 621.05
• DOI: 10.7567/APEX.10.015501
• Languages: English
• ISSNs: 1882-0778

Abstract

Abstract: We report a new method of obtaining the metastable phase form II crystals of acetaminophen. Solution-mediated phase transformation (SMPT) from trihydrate into form II is utilized to obtain form II crystals. SMPT is triggered by seeding form II crystals into a saturated solution including trihydrate crystals, which are less stable than form II crystals. Form II seed crystals gradually grew at the expense of the dissolving trihydrate crystals, and finally, all the trihydrate crystals in solution were transformed into form II crystals in about 4 h. Thus, we conclude that SMPT is effective for the production of form II crystals.