Effect of Eu doping concentration on fluorescence and magnetic resonance imaging properties of Gd2O3:Eu3+ nanoparticles used as dual-modal contrast agent. (3rd August 2018)

• Record Type: Journal Article
• Authors: Deng, Huawei; Chen, Fei; Yang, Chuan; Chen, Min; Li, Li; Chen, Dihu
• Is Part Of: Nanotechnology. Volume 29:Number 41(2018)
• Publication Date: 2018-08-03
• Subjects: dual-modal -- Gd2O3:Eu3+ -- nanoparticles -- laser ablation in liquid -- doping concentration; Nanotechnology -- Periodicals; Nanotechnology -- Periodicals; Nanotechnology; Publications périodiques; Nanotechnologies; Periodicals; 620.5
• DOI: 10.1088/1361-6528/aad347
• Languages: English
• ISSNs: 0957-4484

Abstract

Abstract: Europium-doped gadolinium oxide (Gd2 O3 :Eu 3+ ) nanoparticles (NPs) with favorable properties for use in fluorescence imaging (FI) and magnetic resonance imaging (MRI) dual-modal contrast agent has attracted intense attention in biomedical applications. However, limited information is available on balancing FI and MRI by adjusting doping concentrations. In this study, Gd2 O3 :Eu 3+ NPs with various Eu 3+ doping concentrations were prepared by the facile and general technique of laser ablation in liquid (LAL). The influence of Eu 3+ -doping concentration on fluorescence properties and longitudinal relaxivity were investigated. The optimum Eu 3+ -doping concentration with both high fluorescence properties and longitudinal relaxivity was determined to be 5%. The characterization of the structure, morphology, and composition shows that these NPs possess good crystallinity and excellent dispersibility. These results show that Gd2 O3 :Eu 3+ NPs prepared by LAL are promising candidates for highly efficient FI and MRI dual-modal contrast agents.