Histologic findings and viral antigen distribution in natural coinfection of layer hens with subgroup J avian leukosis virus, Marek's disease virus, and reticuloendotheliosis virus. (September 2019)

• Record Type: Journal Article
• Authors: Liu, Hongmei; Ma, Kui; Liu, Miaomiao; Yang, Chengcheng; Huang, Xueting; Zhao, Yu; Qi, Kezong
• Is Part Of: Journal of veterinary diagnostic investigation. Volume 31:Number 5(2019:Sep.)
• Page Start: 761
• Page End: 765
• Publication Date: 2019-09
• Subjects: antigen distribution -- chickens -- coinfection -- Marek's disease virus -- reticuloendotheliosis virus -- subgroup J avian leukosis virus; Veterinary medicine -- Diagnosis -- Periodicals; 636.0896075
• DOI: 10.1177/1040638719868274
• Languages: English
• ISSNs: 1040-6387

Abstract

We investigated the histologic findings and viral antigen distribution in 3 cases of natural coinfection of layer hens with subgroup J avian leukosis virus (ALV-J), Marek's disease virus (MDV), and reticuloendotheliosis virus (REV) in hens. At autopsy, diseased hens were found to have hepatosplenomegaly and thickened proventriculi, with white tumor nodules in the liver, spleen, lung, kidney, and ovary. Microscopically, most tissues had been infiltrated by neoplastic lymphocytes; the spleen, lung, proventriculus, heart, and liver had been infiltrated by both neoplastic lymphocytes and myeloblastic cells and/or primitive reticular cells. Fluorescence multiplex immunohistochemistry staining revealed ALV-J, MDV, and REV antigens co-expressed in the same tissue, even the same cell.