ZnO-functionalized mesoporous inner-empty nanotheranostic platform: upconversion imaging guided chemotherapy with pH-triggered drug delivery. (9th October 2018)

• Record Type: Journal Article
• Authors: Wang, Lijia; Cai, Ying; An, Zhengbin; Gu, Wenhong; Chen, Ping; Cai, Qingyun
• Is Part Of: Nanotechnology. Volume 29:Number 50(2018)
• Publication Date: 2018-10-09
• Subjects: mesoporous inner-empty -- nanotheranostic platform -- drug delivery; Nanotechnology -- Periodicals; Nanotechnology -- Periodicals; Nanotechnology; Publications périodiques; Nanotechnologies; Periodicals; 620.5
• DOI: 10.1088/1361-6528/aae0b6
• Languages: English
• ISSNs: 0957-4484

Abstract

Abstract: Here we report a novel drug delivery system using mesoporous inner-empty upconversion microspheres carrying drugs with ZnO quantum dots (UCMPS@ZnO) acting as a 'door-keeper' for pH-triggered drug release. Compared to other upconversion drug delivery systems, it is smarter, simpler, more efficient and more biocompatible. In particular, the UCMPS@ZnO microspheres show low cytotoxicity, are simple to produce and have a high drug loading rate (15%). Promisingly, a mice treatment experiment demonstrated that the multifunctional nanoparticles have efficient inhibition of tumor growth after a 14-day treatment. This makes UCMPS@DOX–ZnO microspheres a promising theranostic candidate in cancer treatment and clinical trials.